Crisis on Infinite Earths Giant #1 features a 24-page main story co-written by comics icon and Crisis comic co-creator Marv Wolfman and Marc Guggenheim, who serves as showrunner and executive producer of the Crisis on Infinite Earths television crossover event, with art provided by Tom Derenick (pencils), Trevor Scott (inks), John Kalisz (colors) and Wes Abbott (letters). Wolfman and Guggenheim also contribute an eight-page back-up story with pencils by fan-favorite Superman and Titans artist Tom Grummett, inks by Danny Miki, colors by Chris Sotomayor and letters by Wes Abbott.
The debut issue also features a full reprint of the first issue of Wolfman and Perez' Crisis on Infinite Earths #1 as well as an excerpt from issue #7 of the landmark maxiseries.